Effect of Ag and Ni-Doped Cerium Oxide Nanoparticles on the Formation of ROS and Evaluation as an Alternative Physical Sunscreen Material.

CeO2 nanoparticles (nanoceria) were proposed as an alternative physical sunscreen agent with antioxidant properties and comparable UV absorption performance. Green synthesis of nanoceria with Ag and Ni dopants resulted in doped nanoceria with lower catalytic activity and biologically-safe characteristics. The doped nanoceria was characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Rancimat Instrument, and UV-Vis Spectrophotometer for SPF (Sun Protection Factor) determination. XRD and TEM analysis showed that nanoceria had been successfully formed in nanoscale-sized with a change in crystallite size due to the crystal defect phenomenon caused by dopant addition. While the Rancimat test and band gap energy analysis were conducted to evaluate the oxidative stability and reactive oxygen species formation, it was confirmed that dopant addition could decrease catalytic activity of material, resulting in Ni-doped Ce with a longer incubation time (11.81 h) than Ag-doped Ce (10.58 h) and non-doped Ce (10.30 h). In-vitro SPF value was measured using the thin layer technique of sunscreen prototype with Virgin Coconut Oil (VCO)-based emulsion, which yielded 10.862 and 5.728 SPF values for 10% Ag-doped Ce and 10% Ni-doped Ce, respectively. The dopant addition of nanoceria could reduce catalytic activity and give a decent in vitro UV-shielding performance test; thus, Ag and Ni-doped nanoceria could be seen as promising candidates for alternative physical sunscreen agents.

Development of Flexible Medical Electrodes Using Carrageenan-Based Bioplastics with the Addition of Conductive Hybrid Materials Graphite and Silver Nanoparticles.

Electrodes are crucial in medical devices, specifically health monitoring devices for biopotential measurements such as electrocardiography, electromyography (EMG), and electroencephalography. The commonly used rigid electrodes have limitations in their skin-electrode contact quality since they cannot conform to the skin's surface area and body contours. Flexible electrodes have been developed to better conform to the body's surface contours, improving ion transfer and minimizing motion artifacts, thereby enhancing the signal-to-noise ratio (SNR). Bioplastic substrates based on carrageenan have been chosen for their safety, abundance, flexibility, and ease of customization. Hybrid materials of graphite and silver nanoparticles (graphite-AgNPs) exhibit high electron capacitance, low charge transfer resistance, and superior surface catalytic activity. These make them ideal as conductive fillers for bioplastics to achieve good electrical characteristics as electrodes. The effect of the graphite-AgNP filler concentration, graphite particle size, and flexible electrode thickness was evaluated to assess their impact on the electrical and mechanical properties of the fabricated flexible electrodes. The graphite-AgNP fillers were incorporated into a bioplastic matrix, resulting in flexible electrodes with improved conductivity with increasing percentages of graphite-AgNP at the expense of flexibility. The thickness of the flexible electrode was varied to evaluate its effect on the conductivity. A graphite size reduction was performed to improve the electrical properties while maintaining the mechanical properties. The most optimal variation of flexible electrodes with desirable electrical and mechanical properties was achieved by adding 25% graphite-AgNP to the carrageenan, using graphite particles of 400-700 nm, and using the thinnest electrode. The optimized electrode also exhibited an improved SNR value in EMG signal measurements compared to conventional Ag/AgCl electrodes. This research presents a novel approach to developing environmentally friendly, customizable, and flexible electrodes for medical applications.